Cardiology and Vascular Studies

The following studies are being carried out at the Somerset Foundation Trust.

AZURE-OUTCOMES : A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Effect of AZD0780 on Major Adverse Cardiovascular Events in High Risk Participants with Atherosclerotic Cardiovascular Disease and Elevated Low-Density Lipoprotein Cholesterol.

PROTECT-HF : Physiological vs Right ventricular pacing Outcome Trial Evaluated for bradyCardia Treatment

COSIRA-II : Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II (COSIRA-II)

EASY-AS : A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis

EVEREST : A Randomised Controlled Trial of Renin-Angiotensin Inhibition for Cardiovascular Events Reduction after Takotsubo Cardiomyopathy .

MARITIME-CV : A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants with Atherosclerotic Cardiovascular Disease and Overweight or Obesity

ORION-4 : A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease.  For more information visit the ORION 4 website.

For more information please contact CVResearchTeam@somersetft.nhs.uk