Mental Health, Dementia, Neurodegenerative

The following studies are being carried out at the Somerset Foundation Trust.

MENTAL HEALTH STUDIES 

A Register for New Anti-Epileptic Drugs In ID/PDD populations

All patients with epilepsy and learning difficulties, on specific medication will be contacted by Research team.

Planned end date 30/11/2024

PPiP2 – Prevalence of Neuronal Cell Surface Antibodies in Patients with Psychotic Illness

The study aims to understand more about the role of the immune system in psychosis. There is some evidence to suggest that in some people their immune system may play a part in their symptoms of psychosis.

The immune system normally controls our ability to fight infection.  If the immune system goes wrong it may attack our own body, causing diseases called ‘autoimmune’ diseases.  It has been discovered that some of these autoimmune diseases can affect the brain, and in the early stages of the disease they can manifest through symptoms of psychosis.

We can diagnose some of these autoimmune diseases using blood tests to detect specific antibodies.  We are specifically interested in NMDAR, LGI1, GABA-A and CASPR2 antibodies that may be associated with symptoms of psychosis. Participants with presence of these antibodies in their serum will be referred to neurologist and approached for the SINAPPS2 trial on immunotherapy (IVIG/Rituximab) for antibody associated psychosis.

For further details please visit the website www.sinapps.org.uk

 

Molecular Genetics of Adverse Drug Reactions (MOLGEN)

Molecular genetics of adverse drug reactions: from candidate genes to genome wide association studies. All patients who have a red clozapine result are approached for a one off blood sample.

On hold to recruitment.

NCISH

National Confidential Inquiry into Suicide and Homicide by People with Mental Illness.

Planned end date for recruitment 04/01/2022

RESTORE-LIFE

A Global PRospective, Multi-cEnter, ObServational post-markeT Study tO assess shoRt, mid and long-term Effectiveness and efficiency of VNS Therapy® as adjunctive therapy in reaL-world patIents with diFficult to treat dEpression.

Planned end date for recruitment 01/11/2022

 

DNA Polymorphisms in Mental Health – 3 Arms Healthy Volunteer Arm, Bipolar and Schizophrenia

Long standing study that has recently gained further funding and extending recruitment

 

MENTAL HEALTH STUDIES – IN SET UP

Currently none

 

NEUROLOGICAL STUDIES 

Parkinson’s Family Project

To identify genetic variants that predispose to or cause Parkinson’s disease or Parkinsonism (Parkinson’s diseases – PD) Secondary: To identify families that may be prepared to participate in translational research related to PD, its aetiology, biology, progression and future treatment

Further information about the trial can be found on the Parkinsons website.

Study Closes: 01/01/2027

Chief-PD

This trial aims to determine whether the drug, rivastigmine, can prevent falls in people with Parkinson’s.

Principle Investigator – Dr Anita Goff

For more information, please visit the CHIEF-PD Trial webpage.

Recruitment end date – 30/08/2022

The UK MS Register Project

The UK MS Register project is a joint initiative between Swansea University, the Multiple Sclerosis Society and a number of senior clinicians and academics at NHS Hospitals across the United Kingdom. The goal of the Register is to build a longitudinal research-ready database of people with MS in the UK, consisting of linked data from clinicians, people with MS, and routine MS data.

NHS Clinical Sites consent patients over the age of 18 with a confirmed diagnosis of MS who agree to have their medical records (including an established dataset, clinic letters and even MRIs) linked to the MS Register. Routine sources of anonymised data such as Hospital in and outpatient records will be linked to these datasets going forward. The security and confidentiality of this data is of the highest importance and the highest levels of encryption and security throughout its collection, storage and use are in place. All data that researchers have access to is anonymised and nothing identifiable is ever released.

Further information about the trial can be found at https://ukmsregister.org/

Study closes:  08/07/2022

The MS Registry has produced a short video on the data it has collected on MS and COVID-19 and the research that it has generated.