Emergency, ITU and Surgery Clinical Trials
The following studies are being carried out at the Somerset Foundation Trust.
ABBRUPT – A randomised controlled trial to investigate clinical and cost effectiveness of Amiodarone vs Beta Blockade for new onset atrial fibRillation in icU – a Pragmatic sTudy
ASPECT – A Phase III, randomised study of aspirin and esomeprazole chemoprevention in Barrett’s Metaplasia
ASTEROID – Assessment of Surgeon Treatment Equipoise & Randomisation Opinion to Inform trial Design
CEREN-2 – A randomized, double-blind, placebo-controlled, parallel-group, 52-week Phase 3 trial to investigate the efficacy, safety, and tolerability of itepekimab in adult participants with inadequately-controlled chronic rhinosinusitis with nasal polyps
CLARITY PAD – Clopidogrel, Aspirin and Rivaroxaban after revascularisation with angioplasty
GENOMICC – Genetics of susceptibility and mortality in critical care
GRRAND – Getting Recovery Right After Neck Dissection for Head and Neck Cancer
HOT – Hemithyroidectomy or Total-Thyroidectomy in ‘low-risk’ thyroid cancers
MOSAICC – Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury and metabolic acidosis
POLARIS – Pathway of Low Anterior Resection Syndrome relief after Surgery
POP-I – The clinical benefits and cost effectiveness and safety of haematopoietic interventions for patients with anaemia following major emergency surgery: a phase IV, multi-site, multi-arm randomised controlled trial: Peri-op Iron and Erythropoietin (EPO) Intervention Study
PQIP – Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme
REMAP-CAP – Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia
ROSIER – The ROSIER Trial: Requirement For Surgical Intervention After ERCP
SEPTIC – Sepsis Trials in Critical Care
SHORTER – A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis
STARFISH – A randomised controlled trial of STeroid Administration Routes For Idiopathic Sudden sensorineural Hearing loss
TYPHOON – Tonsillectomy Postoperative Haemorrhage Outcomes and Observations National Cohort Study